What did this comment about Tallahassee mean on Lost?

I'm not from America so clearly there is some kind of inside knowledge here that I missed.



In an episode of Lost, Jack says to Sawyer; "Do you even know what Amoxicillin is for?".



Sawyer then replies, "I've been to Tallahassee, something was burning and let's just say it wasn't the sun." (or words to that effect).



Can someone explain the reference to Tallahassee, do people regularly catch STDs there or something?What did this comment about Tallahassee mean on Lost?
Yeah, Tallahassee is one of many spring break locales, so every year you've got thousands of teenages passing through, drinking, smoking pot and, well, generally partying their little butts off. I've never heard any reports about STD's in relation to Tallahassee, but knowing all of that, I'm sure a lot of kids return home with one souvenir that they never actually bought at a store, and most likely wish they didn't have...lol
i live in tally ho lol

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What did this comment about Tallahassee mean on Lost?
Tallahassee actually a has the most NEW cases of ghonorhea (spelling) for several years.



gotta wrap it up down here

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lol, probably it's a pretty wild little city
Tallahassee is the home of Florida State University, which I can confirm as a graduate of this fine institution there are a plethora of beautiful women in attendance.
No, not more than other places. It's just a one of the party places in America. It's just really a joke, and he could have picked "Fort Lauderdale" or "Key West" or "Cancoon" or something like that.
good show.....